#2722
90.0 ct.
Price:
$41.60
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General information
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Ingredients
Glucosamine Plus™ is a proprietary blend of Glucosamine and herbs to support aching joints, the immune system, a healthy metabolism and the digestive system.
How to use
Take one capsule with each meal three times daily.
Storage
Keep out of reach of children!
Caution
As with any nutritional supplement, consult a health care provider prior to use if you are pregnant or nursing, have a medical condition, or are taking any medication.
Works well with
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CetylMobility® - supports immune system function and joint health with cetyl myristoleate and type II collagen.
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Indulge Bubble Bath - helps ease stiff muscles and mental tension with fragrant herbal extracts.
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Anatomix® - developed to ease minor inflammation activated by sulfur deficiency.
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Alleviate™ - supplies the body with antioxidants which neutralize harmful free radicals that can damage DNA molecules and affect cellular health.
125.0 ml (#4501)
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Cypress Essential Oil - acts as an astringent, a tonic for oily skin, a deodorant, and an aid in easing muscle spasms.
15.0 ml (#2830)
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Wild Rosemary Essential Oil - may soothe aching muscles, enhance memory and soothe feelings of nervous exhaustion.
15.0 ml (#2822)
Detailed product description
Reformulated in October, 2003 to provide more powerful nutritional support for healthy joints, Glucosamine Plus™ helps keep your joints in working order.
Glucosamine is an amino monosaccharide derived from glucose, the principal sugar found in blood. It is water soluble and easily absorbed in the small intestine. Glucosamine is a chemical compound of Glucose and an Amine molecule (a nitrogen atom with two hydrogen atoms) that supports the maintenance of the connective tissues in the body. Read clinical summary on Glucosamine...
In glucosamine, one oxygen atom in glucose is replaced with a nitrogen atom. Glucosamine has an affinity for joint cartilage and this cartilage is well adapted for the active uptake of Glucosamine.
Glucosamine is produced naturally in the body where it plays an important role in the support of healthy cartilage – the white, smooth, rubber-like padding that covers the ends of bones and prevents them from rubbing against each other as the body moves. It is also a raw material used in forming ligaments, tendons and nails. In most cases, the joints produce sufficient glucosamine to keep the cartilage in good repair; however, as the body ages it needs supplemental glucosamine to support healthy cartilage function.
Glucosamine supports the healthy production of glycosaminoglycans (GAGs), formerly known as mucopolysaccharides, and proteoglycans (PGs) – two essential building blocks of cartilage. It acts as a raw material for the chondrocytes – cells that are responsible for the synthesis, maintenance, and regeneration of cartilage. When glucosamine is available for chondrocytes, they are able to produce connective tissue faster. Glucosamine also appears to work by providing the once-starved chondrocytes with the raw materials necessary to stimulate the synthesis of GAGs and PGs.
Proteoglycans (PGs) have a negative charge which causes them to attract water molecules. This causes PGs to have a gel-like consistency and the ability to fill space in three dimensions. Collagen fibers give them form. If the body does not make PGs in sufficient amounts, it may suffer impaired cartilage function and accelerated breakdown.
By taking glucosamine supplements, support can be obtained for the natural production of glucosamine by the body. The net result: the body produces more healthy cartilage.
Neways has uniquely formulated products that encourage youthful mobility of flexible joints including the hips, shoulders, knees, elbows, ankles, wrists, fingers, toes, neck, spine and chest. In addition, proper nutrition and exercise will go far to enhance healthy joint movements.
Neways' core products that support healthy joint mobility are CetylMobility®, Anatomix®, Glucosamine Plus™, Cascading Revenol™ and Maximol Solutions®. As a topical application, mixing Agility Essential Oil Blend with Tangible Massage Lotion and massaging the mixture over stiff, sore joints and muscles may provide soothing support for movement.
Glucosamine Clinical Summary
An endogenous aminomonosaccharide synthesized from glucose. Found in mucopolysaccharides, mucoproteins and chitin (a cellulose-like biopolymer that is a major component of the exoskeleton of various marine invertebrates), glucosamine is used in the biosynthesis of proteoglycans and glycosaminoglycans. It is often paired with chondroitin sulfate in the treatment of articular diseases. A meta-analysis of both chondroitin and glucosamine trials shows efficacy in osteoarthritis of the knee 1. Two smaller studies of glucosamine and chondroitin together show efficacy in reducing symptoms in temporo- mandibular joint (TMJ) disorder 2 and degenerative joint disease (DJD) of the knee. No efficacy is seen in relieving back pain 3 or glucose metabolism in patients with type 2 diabetes mellitus 15. A few trials that have not shown efficacy may point to glucosamine's limited effect in older patients who have more severe arthritis 4 or have had arthritis for longer periods of time 5. Generally, glucosamine is as effective as NSAIDs over time with fewer reported side effects. It is frequently slower to act 6 but the effect continues longer after cessation of treatment 7.
Scientific Name
2-Amino-2-deoxyglucose
Also Known As
Glucosamine sulphate, Glucosamine hydrochloride, Chitosamine
Purpoted Uses
- Inflammation
- Osteoarthritis
- Temporomandibular joint disorder (TMJ)
Mechanism of Action
A progressive degeneration of cartilage glycosaminoglycans is evident in osteoarthritis. Glucosamine is the rate-limiting step in glycosaminoglycan biosynthesis and therefore can provide a platform for glycosaminoglycan regeneration and promote joint repair 13. Glucosamine has been shown to increase proteoglycan amounts in vitro, by affecting the synthesis of monomeric proteoglycans capable of assembling into large molecular weight aggregates 7. Glucosamine can protect damage cartilage from metabolic impairment by NSAID's, corticosteroids and by providing anti-inflammatory effects via action other than the inhibition of cyclooxygenase 8 .
Pharmacokinetics
Glucosamine may be administered via intravenous, intramuscular or oral routes. Intravenous and intramuscular administration appears in the plasma and is rapidly eliminated. t1/2 is 0.28h. 1-2 hours after administration, glucosamine or its metabolites have been entirely incorporated into plasma proteins. Oral administration of glucosamine sulfate yields 90% absorption. Incorporation is similar to parenteral administration although the plasma level is five times smaller due to a first pass effect in the liver. After administration or ingestion, glucosamine sulfate is split into D-glucosamine and a sulfate ion. D-glucosamine is a small, neutral molecule that has a special tropism for cartilaginous bone tissue.9
Warnings
Diabetics should check their blood sugar level more frequently as glucosamine could potentially affect insulin level and glucose metabolism in the body.
Individuals should consult their doctor if allergic to shellfish.
Adverse Reactions
Adverse reactions are rare and glucosamine tends to be safe and well tolerated. Reported adverse reactions include: Gastrointestinal complaints, headache, leg pain, edema, itching 8 and possible allergic reactions 2.
Drug Interactions
A study in 10 people found that an infusion of glucosamine sulfate reduced glucose tolerance. This observation and recent in vitro evidence suggest that glucosamine can increase insulin resistance, resulting in the need for larger doses of insulin or oral hypoglycemic agents in diabetic patients 14 .
Lab Interactions
May affect blood glucose level 14.
Literature Summary and Critique
McAlindon TE, et al. Glucosamine and chondroitin for treatment of osteoarthritis: a systematic quality assessment and meta-analysis. JAMA 2000;283:1469-75.
Meta-analysis of 15 RCTs of glucosamine or chondroitin lasting four or more weeks. Studies were given quality scores and showed publication bias. The aggregated effect size for glucosamine was 0.44, which corresponded to moderate effect. Restricting measurement to larger and higher-quality studies diminished the effect size. Nevertheless, some level of efficacy was supported.
Hughes R, Carr A. A randomized, double-blind, placebo-controlled trial of glucosamine sulphate as an analgesic in osteoarthritis of the knee. Rheumatology 2002;41:279-84.
An RCT of 80 patients with osteoarthritis of the knee recruited from a rheumatology out-patient clinic. Patients received either oral glucosamine sulfate 1500 mg daily for six months or placebo. Results showed a statistically significant difference in knee flexion, but no difference in the primary outcome measure of pain. Patients' WOMAC pain, function and stiffness scores were higher than those in trials showing efficacy implying that glucosamine may be effective only for milder osteoarthritis. In addition, patients in this trial were more likely to have received previous pharmacological treatment or were taking NSAIDs at the time of trial. These points may also have affected the outcome of the study. Adverse effects were similar to placebo in this study.
Reginster YJ, et al. Long-term effects of glucosamine sulfate on osteoarthritis progression: a randomized, placebo-controlled clinical trial. Lancet 2001;357:251-6.
An RCT of 212 patients with osteoarthritis of the knee. Patients received either oral glucosamine sulfate 1500 mg daily or placebo for three years. Minimum and mean joint-space width of the medial compartment of the tibiofemoral joints were measured after one and three years. Symptoms were scored by WOMAC. Patients in the treatment arm experienced no joint-space narrowing, whereas patients in the control arm experienced mean joint-space loss of 0.31 mm after three years. In an intention-to-treat analysis, patients showed a statistically significant reduction in WOMAC score after three years. Adverse effects were similar to placebo in this study. This large, well-designed study supports the efficacy of glucosamine in retarding the progression of knee osteoarthritis.
Pavelka K, et al. Glucosamine sulfate use and delay of progression of knee osteoarthritis: A 3-year, randomized, placebo-controlled, double-blind study. Arch Intern Med 2002;162:2113-23.
An RCT of 202 patients with mild to moderate osteoarthritis of the knee. Patients received either oral glucosamine sulfate 1500 mg daily or placebo for three years. Minimum joint space widths were measured in the medial compartment of the tibiofemoral joint and symptoms were measured using Lequesne and WOMAC. Patients in the treatment arm experienced no joint-space narrowing, whereas patients in the control arm experienced joint space narrowing of 0.19 mm. In addition, fewer patients in the treatment arm experienced severe narrowing (>0.5 mm) than in the control group. Statistically significant improvements on the Lequesne and WOMAC scale were found in the treatment group. Adverse effects were similar to placebo in this study. This large, well-designed study supports the efficacy of glucosamine in retarding the progression of knee osteoarthritis.
All prices are in US dollars. Payment should be made in UAH according to the National Bank official rate at the
time of purchase.
This product is not intended to diagnose, treat, cure, or prevent any disease.
All products are made in the USA and certified by the Ukrainian State Committee of Standardization, Metrology and Certification.